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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク RNAi-Based Identification System and interference of Specific Cancer Cells ： ウィキペディア英語版 RNAi-Based Identification System and interference of Specific Cancer Cells A “classifier” was created to classify cells by identifying specific characteristics of Cervical Cancer. These characteristics were consistent with HeLa cells, which served as the target cell line for cell death.〔 Upon identifying these cells the Classifier would release specific proteins within the HeLa cell that would trigger apoptosis without killing or endangering neighboring, healthy cells.〔 The defining characteristics of these Classifiers were defined by elements whose levels within the cells created markers that could be measured.〔 High markers and low markers were established and a “classifier molecule” was created to insert into prospective cells, and would induce apoptosis only when cells exhibit the threshold level of High or Low markers.〔 These classifiers would use a small interfering RNA which targeted the repressor and activator in the Lac operon.〔 The potential for therapeutic use, providing that an efficient delivery system can be established for in vivo DNA. In vitro applications are possible provided the classifier molecule can be safely integrated into cultured cells.〔 == Cancer cell identification and classification == Cancer cells can be classified by identifying the MicroRNA expression. These mRNA expression levels can be used as a diagnostic and prognostic tool in tumor and cancer classifications, although current tumor classification methods do not incorporate experimental knowledge.〔 As is evident in experimental knowledge, different types of cancer can be associated with the irregular expression of particular miRNAs.〔 Other parameters considered to be critical are the location of the miRNAs on the strand, cancer associated genomic regions, epigenetic alteration of miRNA expression and abnormalities in processing target genes and proteins.〔 Recent evidence show that miRNAs play an important role in human malignancies and could act as a tumor/oncogene suppressor.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「RNAi-Based Identification System and interference of Specific Cancer Cells」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.